Genetic Variation of SCN5A in Korean Patients with Sick Sinus Syndrome
نویسندگان
چکیده
منابع مشابه
Genetic Variation of SCN5A in Korean Patients with Sick Sinus Syndrome
BACKGROUND AND OBJECTIVES Due to recent studies that have shown an association between the genetic variation of SCN5A and sick sinus syndrome (SSS), we sought to determine if a similar correlation existed in Korean patients with SSS. SUBJECTS AND METHODS We enrolled 30 patients with SSS who showed a sinus pause (longer than 3.0 s) in Holter monitoring, in addition to 80 controls. All exons in...
متن کاملPatients With Sick Sinus Syndrome
Background. The goal of the report was to study the long-term incidence and the independent predictors for chronic atrial fibrillation and stroke in 507 paced patients with sick sinus syndrome, adjusting for differences in baseline clinical variables with multivariate analysis. Methods and Results. From 1980 to 1989, we implanted 376 dual-chamber, 19 atrial, and 112 ventricular pacemakers to tr...
متن کاملPacing mode selection in patients with sick sinus syndrome.
INTRODUCTION SICK SINUS SYNDROME The sinus node is composed of a collection of specialised pacemaker cells embedded in a fibrous matrix that lies in the sulcus terminalis between the superior vena cava and the right atrial appendage. The sinus node serves as the primary cardiac pacemaker and controls the heart rate in normal individuals. Recent research indicates, that the sinus node is a heter...
متن کاملMechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome.
RATIONALE Familial sick sinus syndrome (SSS) has been linked to loss-of-function mutations of the SCN5A gene, which result in decreased inward Na(+) current, I(Na). However, the functional role of I(Na) in cardiac pacemaking is controversial, and mechanistic links between mutations and sinus node dysfunction in SSS are unclear. OBJECTIVE To determine mechanisms by which the SCN5A mutations im...
متن کاملThe sick sinus syndrome.
1. a. SSS b. SA block c. SA arrest Sick sinus syndrome is a disorder characterized by a dysfunctional sinus node. It is often idiopathic and a result of degenerative fibrosis of nodal tissue. Certain disorders such as amyloidosis, connective tissue disease, Chagas disease, and hemochromatosis are examples of intrinsic causes. Hypertensive heart disease and cardiomyopathies account for a smaller...
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ژورنال
عنوان ژورنال: Korean Circulation Journal
سال: 2016
ISSN: 1738-5520,1738-5555
DOI: 10.4070/kcj.2016.46.1.63